SLE-like and sicca symptoms in late component (C9) complement deficiency.
نویسندگان
چکیده
منابع مشابه
SLE-like and sicca symptoms in late component (C9) complement deficiency.
Hereditary deficiencies in early and late complement components are well known to predispose to SLE-like syndromes or recurrent infection. Hitherto reported C9 deficient cases have usually been healthy subjects, however, and it is not considered that C9 deficiency is associated with any specific disease. We describe a completely C9 deficient patient with possible Sjögren's syndrome and discuss ...
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ciency. Diagnosis and HLA studies in a French-Canadian family. J Clin Invest 60:1061–1069, 1977. 24. Zeitz HJ, Miller GW, Lint TF, et al. Deficiency of C7 with systemic lupus erythematosus: Solubilization of immune complexes in complement-deficient sera. Arthritis Rheum 24:87–93, 1981. 25. Alcalay M, Bontoux D, Peltier A, et al. C7 deficiency, abnormal platelet aggregation, and rheumatoid arthr...
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Background and Objectives: Complement proteins are some of the most important plasma proteins of the innate immune system. Impaired immune function is reported in subjects who are iron deficient, and there are documents that these patients are prone to infection. This study was conducted to show whether serum C3 and C4 complement change in adult nonpregnant female with iron deficient anemia or ...
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Using specific immune sera, C7, C9, and C3 activator were detected in sera from human fetuses more than 16 weeks old and in newborn samples. Levels of C9 in cord sera ranged between 10 and 30% of those present in sera from adult subjects. The mean value of Ce activator was about half that in maternal blood. The mean level of C7 in newborns was nearly 70% of the amount in normal adults.
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The complement system has important protective functions in both the innate and the adaptive immune systems but can also, when inappropriately activated, cause tissue damage. Complement deficiency predisposes to infection and also to development of autoimmune disease, especially SLE, and complement is at the same time involved in the pathogenesis of this disease. In this review, various aspects...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1987
ISSN: 0003-4967
DOI: 10.1136/ard.46.2.153